Variable directionality of gene expression changes across generations does not constitute negative evidence of epigenetic inheritance
نویسندگان
چکیده
منابع مشابه
Variable directionality of gene expression changes across generations does not constitute negative evidence of epigenetic inheritance
Transgenerational epigenetic inheritance in mammals has been controversial due to inherent difficulties in its experimental demonstration. A recent report has, however, opened a new front in the ongoing debate by claiming that endocrine disrupting chemicals, contrary to previous findings, do not cause effects across generations. This claim is based on the observation that gene expression change...
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A previous report claimed no evidence of transgenerational epigenetic inheritance in a mouse model of in utero environmental exposure, based on the observation that gene expression changes observed in the germ cells of G1 and G2 male fetus were not in the same direction. A subsequent data reanalysis however showed a statistically significant overlap between G1 and G2 genes irrespective of direc...
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The study of epigenomic variation at the landscape-level in plants may add important insight to studies of adaptive variation. A major goal of landscape genomic studies is to identify genomic regions contributing to adaptive variation across the landscape. Heritable variation in epigenetic marks, resulting in transgenerational plasticity, can influence fitness-related traits. Epigenetic marks a...
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ژورنال
عنوان ژورنال: Environmental Epigenetics
سال: 2015
ISSN: 2058-5888
DOI: 10.1093/eep/dvv005